The ANZTCT Registry

Projects & Research

Current Projects

  • Paediatric αβ haploidentical transplantation (Pαβlo)

    This is a prospective phase II study of the safety and cost-effectiveness of paediatric patients receiving TCR α+β+/CD19+ cell depleted haploidentical donor stem cell transplantation compared to those receiving an alternate donor haematopoietic stem cell transplant.

  • Haploidentical peripheral blood stem cell transplantation with post-transplant cyclophosphamide as GVHD prophylaxis

    This phase II study will involve 6 transplant centres from Australia and New Zealand and is the ABMTRR's first prospective study. It is supported by a grant from the Arrow Bone Marrow Transplant Foundation, which enabled database enhancements to streamline data management for this and future registry studies.

  • Prophylactic early parenteral nutrition in BMT

    This multicentre randomised controlled trial is an NHMRC funded study evaluating the effect of supplemental prophylactic early parenteral nutrition commenced prior to chemoradiotherapy compared to pragmatic standard nutrition care on disease free survival in patients about to commence conditioning chemoradiotherapy for allogeneic haematopoietic progenitor/stem cell transplantation. The ABMTRR will be providing long term outcome data for this study.

  • Non-relapse mortality in unrelated donor transplants

    The number of unrelated donor transplants performed in Australia and New Zealand has increased markedly in the past 15 years. This retrospective analysis will examine the impact of changes in practice over this time, such as greater availability of fully matched donors, use of reduced intensity conditioning, graft vs host disease prophylaxis and supportive care.

  • The effect of genotype on transplant outcomes

    This laboratory study is being done by Westmead Institute for Medical Research in conjunction with the ABMDR, analysing donor-recipient tissue samples. The ABMTRR is providing transplant outcome data so that the researchers can determine any effect of genotype on transplant outcome.

Future Research

The ABMTRR welcomes collaborative research. We believe that the utility and quality of the Registry is improved by the active participation of clinicians and researchers. While the fundamental role of the ABMTRR is to maintain accurate and current data, extension of this role to include extra data collection and analysis is available on a cost recovery basis.

All research proposals must first be presented to the Steering Committee for approval. Once a project has been approved, any associated costs beyond the core business of the ABMTRR are borne by the researcher.

Our study management capacity has been enhanced by database modifications generously funded by the Arrow Bone Marrow Transplant Foundation.

Please Contact Us if you would like to discuss a potential project.

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