SOS/VOD Guidelines

Background Definition Hepatic Sinusoidal Obstruction Syndrome (SOS), also known as hepatic Veno-occlusive Disease (VOD) is a serious and potentially fatal complication that can occur following Blood or Marrow Transplantation (BMT) in both adult and paediatric patients. Pathophysiology SOS/VOD is caused by toxic injury to hepatic venuls and sinusoidal endothelial cells from the conditioning therapy of…

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